منابع مشابه
Life after GWAS: functional genomics in vascular biology.
The chromosome 9p21 (Chr9p21) locus was discovered in 2007 by independent genome-wide association studies for coronary artery disease. Since then, the locus has been replicated numerous times and can be considered the most robust genetic marker of coronary artery disease today. Subsequent work has shown associations of Chr9p21 with a number of additional cardiovascular disease traits, such as c...
متن کاملATVB in Focus Life After GWAS: Functional Genomics in Vascular Biology
Recent genome-wide association studies have identified hundreds of genetic loci as being associated with vascular diseases or traits and their risk factors. Many of the loci uncovered represent novel discoveries with no obvious candidate genes and molecular mechanisms, testifying to the complexity of vascular diseases. To understand the functional consequences of genetic variations and help pin...
متن کاملGwas
That’s interesting. Care to elaborate? Part of the problem in trying to make a movie about real animals is that they aren’t actors. You can write a script — and there was one — but the chimps didn’t always follow it! So, like a good field worker, one had to adapt as the film footage came in and the story line changed. In this day and age of global warming, disease pandemics, and the like, it’s ...
متن کاملDigesting GWAS
nce upon a time, medical genetics was a relaOtively straightforward business: one gene—one protein—one disease was sufficient to explain most inherited disease and was neatly in keeping with Gregor Mendel’s discovery of alleles with his famous peas. The concept remains a good starting point but the biology of life is somewhat more complex, and increasingly we have become impressed and perplexed...
متن کاملGWAS in lung disease.
We read with interest the recent article ‘Genome-wide association studies in lung disease’ by Artigas et al. While we agree that a greater understanding of the biological pathways underlying disease development and progression (susceptibility) will be a major outcome from these genetic epidemiological studies, we suggest other benefits may also stem from this research. The genetics of chronic o...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2012
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.111.243543